The various extracts of Tephrosia purpurea were investigated for its anti-arthritic activity in male albino rats. The evaluation of anti-arthritic activity was carried out using Freund’s adjuvant induced arthritis model. Dexamethasone (0.1 mg/kg) was used as a standard drug. The ethanolic extract of Tephrosia purpurea exhibited significant anti-arthritic activity as compared to other extracts. The doses of 200 and 400 mg/kg of the ethanolic extract of Tephrosia purpurea, Biochemical parameters were assayed. Rheumatoid factor, C-reactive protein (CRP), Superoxide dismutase (SOD), Catalase (CAT). The ethanol extract at the dose of 300 mg/kg body weight inhibited the rat paw edema, which is comparable with standard drug Dexamethasone, inhibition of rat paw edema after 21 days. The results of the current investigation concluded, ethanol extract of Tephrosia purpurea Linn, possess a significant anti-arthritic activity against adjuvant induced arthritis and justifying its therapeutic role in arthritic condition.
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